make a difference：意思是对某事产生巨大的影响或者作用，尤其是好的方面。
make a difference :有关系，有影响，有重要性
make no difference：没有关系，没有重要性
有关短语：make a big/ a great deal of / a lot of difference
例句:
The fact that I can now organize my own time makes a big difference.
现在我能自己安排时间了，这对我有很大的作用。
Make a difference between：treat differently
区别对待；不同样对待
It will make a very big difference.
这将造成很大的差别。
It would make a very big difference.
这将造成很大的差别。
too small to make a significant difference.
小到不能产生有意义的区别。
It do not make a blind bit of difference.
这根本没关系。
It does not make a blind bit of difference.
这根本没关系。
One false step will make a great difference.
失之毫厘，谬以千里。
Flowers make no/a/some/difference to a room.
鲜花（没有）使房间有所不同。
A false step will make a great difference to my future.
错走一步对我的前程来说会产生很大影响。
It doesn't make a blind bit of difference.
这根本没关系。
Regardless of your circumstances,you can make a difference.
不管所处的条件如何，你可以出人头地，特别是在你现任的工作中。
If you do so it will make a great difference.
如果你那样做，影响就大了。
We must make a difference between the two types of contradiction.
我们必须区别对待这两种矛盾。
It make no difference if you light a lamp in the sunshine.
白天点灯多此一举。
She told the teens how they could make a difference right now.
她告诉这些十几岁的孩子们他们怎样可以现在就做出一些有意义的事情来。
Giving out to others in an effort to make a difference had taken its toll.
为别人付出，努力让自己发挥点作用，已经使我精疲力竭。
You have to be very exact in this job, because a small mistake can make a big difference.
你做这项工作必须十分严谨，因为一点小的失误也会造成很大差异。
It doesn't make a bit of difference. We can go fishing in the rain.
那没多大关系。我们可以在雨中垂钓。
make a difference on " nation building" issues like economic empowerment, conflict resolution and community service.
争取在经济事务、冲突解决方案和社区服务之类的重大问题上发挥重要作用。
As teachers, you must believe that you can make a difference to the lives of your students.
身为教师，你们必须坚信你们能够影响学生的一生。
Whether endowed with a silver spoon or burdened with poverty does not make much difference after all.
一个人生来富贵或贫穷毕竟没有多大的区别。
The teacher believes that he or she is responsible for making a difference in his or her students’ learning.教师应该坚信其有责任影响学生的学习情况
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